A collaboration between Thermo Fisher Scientific and SRI International enables researchers to combine the results of high-resolution Orbitrap LC/MS experiments with curated and organism-specific metabolic pathway and genome data for quick and effective mass spectrometry-based small molecule research and analysis. Researchers now have a direct link between the Thermo Scientific Compound Discoverer 2.1 software platform for small molecule research and SRI International’s BioCyc, a collection of 9300 databases that provide electronic reference sources on the metabolic pathways and genomes of many organisms. The ability to automatically and interactively overlay statistical data onto these pathways can facilitate the biological interpretation of results obtained from a metabolomics experiment.