Thermo Scientific Compound Discoverer 3.3 software can detect more compounds in less time, thanks to faster and more sensitive peak detection. The new software provides peak quality reporting to help determine and filter relevant compounds, streamlining the data review process. Scientists can improve confidence in compound annotations through MSn spectral tree search capabilities in tandem with the Thermo Scientific mzCloud spectral library. Compound Discoverer 3.3 software has been optimised for processing large datasets and detecting low-abundance compounds.