Prosolia has introduced a new desorption electrospray ionisation (DESI) 2D model compatible with Agilent TOF, Q-TOF and IM-Q-TOF LC/MS systems. With no sample prep required, DESI 2D enables molecular imaging without matrix by mass spectrometry. DESI 2D integrates real time, micro-scale solvent extraction in fast-moving droplets with electrospray ionisation for direct sample analysis. DESI 2D incorporates Prosolia’s proprietary DESI technology and is currently used in preclinical and clinical research for determining the distribution of drugs, metabolites and biomarkers of disease, as well as, a variety of chemical analysis applications.