Thermo Fisher Scientific introduced the Orbitrap Fusion Lumos Tribrid mass spectrometer designed for advanced proteomics, biopharma and metabolomics applications. The new instrument has a new ion source which enables up to 5× improvement in limits of quantitation for peptides and small molecules. The segmented quadrupole mass filter increases sensitivity by improving isolation resolution, ion transmission and peak shape. High definition electron transfer dissociation improves dynamic range and detection limits by performing ETD on a larger precursor ion population. ADAPT technology adjusts key parameters “on-the-fly” without prior knowledge of sample amount, enabling maximum protein identifications from samples of unknown concentration in a single run.