Shimadzu Scientific Instruments has introduced the Nexera Mikros Microflow liquid chromatography mass spectrometry system covering the complete range from microflow to semi-microflow. System configuration options include a direct injection system for sample volume-limited analyses for rapid and highly sensitive micro LC-MS analysis without sample loss. A trap and elute system is available for analyses with larger injection volumes or when some degree of sample cleanup is desirable. A make-up flow system includes the addition of a post-column make-up flow pump, allowing mobile phase modifiers to be added to ensure the highest ionisation efficiency in the MS source.