The purpose of this short review article is to highlight some capabilities of qNMR spectroscopic methods in drug quality evaluation, indicating that qNMR spectroscopy should be more often applied when chromatographic methods are not working effectively.
Spectroscopy Articles
Displaying 221–240 of 302 results
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Issue 19/5 (2007)
Knowledge of the absolute configuration of asymmetric, chiral carbon atoms is essential for the understanding of enzyme mechanisms, drug action and structure–function relations, as well as for the determination of biological structure. For example, the right-handed alpha helix in proteins and DNA (both right-handed B and left-handed Z) are all based on the knowledge of the absolute configuration of their building blocks, amino acids and nucleic acids, respectively. Knowledge of the absolute configuration is crucial in the discovery, development and the registration of drugs. The independent determination of the absolute configuration is commonly achieved by single crystal X-ray analysis making use of anomalous dispersion. However, crystals of suitable quality are required for this technique. Moreover, the crystal should preferably contain a heavy atom, such as chlorine or heavier, for the anomalous dispersion technique to work. In this article we describe a technique for determining absolute configurations in solution.
Issue 19/4 (2007)
Our focus here is analytical procedures and the role of nuclear magnetic resonance (NMR) in particular. These have, until now, largely relied on conventional chromatography, and vibrational spectroscopy—infrared (IR), Raman and near infrared (NIR) spectroscopy. In spite of inherent difficulties with peak assignment and reliable quantification, vibrational spectroscopy has been used to derive information on reaction progression to impart fundamental understanding. This article sets out a wider scope to show how NMR can play a key role. Furthermore, NMR integrates well with established procedures to provide a suite of useful technologies that make the PAT challenge tractable.
Issue 19/4 (2007)
We will consider here the analytical aspects involved in the measurements of illicit drugs and their metabolites in wastewater samples by HPLC-MS/MS.
Issue 19/4 (2007)
Raman spectroscopy was used to study the condition of the Victory sail. Molecular spectroscopic analysis of the sail fibres was needed to simulate the aged, degraded material, thereby effecting a better compatibility between the old and replacement materials which would assist in the preservation of this ancient, historic marine textile.
Issue 19/3 (2007)
X-ray fluorescence spectrometry could be a good analytical tool for trace metal analysis of vegetation samples as an alternative to classical destructive methods, given that it provides accuracy and precision fulfilling the requirements for environmental studies.
Issue 19/3 (2007)
In the post-genome era, the focus of life science is shifting to proteins. Based on the difference between the various states of the protein, time resolved Fourier transform (tr-FT-IR) spectroscopy can selectively detect, with nanosecond resolution, reactions of the amino acids, the ligands and specific water molecules in the active centre of the protein, thereby providing a detailed understanding of the reaction mechanism. Malfunctioning of proteins is the cause of many diseases. Thus, the understanding of structure, function and interaction of proteins at the molecular level is essential for the development of drugs for a rational molecular therapy.
Issue 19/3 (2007)
This article focusses on the application of near infrared (NIR) spectroscopy as a potential substitute to the sensory evaluation of tea quality.
Issue 19/2 (2007)
The University of Leicester began an investigation to determine whether useful information on PAN (Peroxyacetyl nitrate) could be obtained from MIPAS data using the MSF absorption cross-sections.
Issue 19/2 (2007)
The authors show how the use of SIAM method (Species Identification of Animals MALDI-TOF mass spectrometry) is a fast and reliable tool for recognising the origin of mammalian species.
Issue 19/2 (2007)
The author looks at the origins and research at the Molecular Spectroscopy Facility (MSF) at the Rutherford Appleton Laboratory (RAL).
Issue 19/1 (2007)
The authors report on an analytical technique based on the combination of attenuated total reflection infrared (ATR-IR) spectroscopy and modulation excitation (ME), which enables the investigation of the interactions leading to separation at the selectand—selector interface.
Issue 19/1 (2007)
The aim of this study is to compare two of the most applied digestion methods for heavy metals determination in calcareous soils, evaluating the most effective and useful digestion method to be applied to agricultural soils devoted to growing vegetable crops in the Valencian Mediterranean region, a representative area of the European Mediterranean region.
Issue 19/1 (2007)
John F. Watts
Surrey Materials Institute and School of Engineering, University of Surrey, Guildford, Surrey GU2 7XH, UK. E-mail: [email protected]
Andreas Richter
Institute of Environmental Physics, University of Bremen, Bremen, Germany. E-mail: [email protected]
J.I. Baumbacha and M. Westhoffb
aISAS—Institute for Analytical Sciences, Department of Metabolomics, Bunsen-Kirchhoff-Straße 11, 44139 Dortmund, Germany
bLung Hospital Hemer, Theo-Funccius-Str. 1, 58675 Hemer, Germany
Geoffrey Duxbury and Nigel Langford
Scottish Universities Physics Alliance, Department of Physics, John Anderson Building, University of Strathclyde, 107 Rottenrow East, Glasgow G4 0NG, UK. E-mail: [email protected], [email protected]
Erik Skibsted
Novo Nordisk, CMC Supply, Analytical Development, Denmark. E-mail: [email protected]
Jens Petter Wold
MATFORSK, Norwegian Food Research Institute, Osloveien 1, 1430 Ås, Norway
G. Langergraber,a J. van den Broeke,b,* W. Lettlb and A. Weingartnerb
aInstitute for Sanitary Engineering and Water Pollution Control, BOKU - University of Natural Resources and Applied Life Sciences, Vienna, Muthgasse 18, A-1190 Vienna, Austria. E-mail: [email protected]