The new Thermo Scientific Orbitrap Exploris 120 mass spectrometer has fast scanning modes and rapid polarity switching. It is compatibile with Thermo Fisher’s latest software, including Compound Discoverer 3.2, providing extensive characterisation capabilities, access to multiple mass spectral fragmentation library and structural database sources, and TraceFinder 5.1 software, which simplifies and optimises the high-throughput screening and quantitation of compounds with improved integration of difficult peaks and streamlined reporting.